PhD student in Biophysics

The Department of Biochemistry and Biophysics is mainly located with the other Departments of Chemistry and Life Sciences in the Arrhenius Laboratories for Natural Sciences which are situated in the northern part of the University Campus at Frescati. Some 270 people of which about 60 are PhD students work at the Department engaged in internationally highly recognised research covering a broad range of subjects.

SciLifeLab (SciLifeLab) is a national center for molecular biosciences with a focus on health and environmental center combines frontline technical expertise with advanced knowledge of translationalmedicine and molecular bioscience. SciLifeLab is a national resource hosted by Karolinska InstitutetKTH Royal Institute of Technology Stockholm University and Uppsala University. The center alsocollaborates with several other universities.

The employment will be placed at the Department of biochemistry and biophysics at Stockholm university.

More information about us please visit: the Department of Biochemistry and Biophysics.

Project description

Project title: Advanced Light Microscopy for Multiple Sclerosis Research

The Computational Microscopy for Cell Biology (CMCB) laboratory led by Assistant Prof. Juliette Griffié based at SciLifeLab is recruiting a highly motivated PhD student for an interdisciplinary project in collaboration with Associate Prof. Nicolas Ruffin (Department of Clinical Neuroscience co-supervisor) at Karolinska Institutet (KI).

The project aims to investigate the molecular and cellular drivers of Multiple Sclerosis (MS) using advanced light microscopy approaches including super-resolution microscopy particular the research will focus on understanding the role and phenotype of B cells in MS. While B cells are now recognized as central players in disease progression and represent highly promising therapeutic targets many aspects of their molecular organization and functional states remain poorly understood. By combining advanced imaging and quantitative analysis this project seeks to uncover novel biological mechanisms underlying MS. The project sits at the intersection of immunology advanced microscopy and quantitative biology and is particularly suited for candidates excited about addressing fundamental biomedical questions using cutting-edge imaging technologies.

We are seeking exceptional candidates with an MSc degree in biology biochemistry immunology biophysics bioengineering or related disciplines. Strong hands-on experience in wet-lab experimental work is essential particularly sample preparation for fluorescence microscopy. Prior experience with advanced light microscopy and immune cell culture is highly desirable. Experience with super-resolution microscopy image analysis or programming is considered a strong advantage but the primary focus of the position is experimental and microscopy-based expertise. A strong interest in MS research and immunology is essential.

The selected candidate will join a highly interdisciplinary and international research environment composed of physicists engineers biologists biochemists and computational scientists. The CMCB laboratory develops cutting-edge microscopy computational and AI-driven approaches to investigate biological systems across scales ranging from molecular organization in cells to multimodal AI for biology and health. The project will vastly benefit from these close interactions between experimental biology advanced imaging and quantitative analysis within the research group.

The position is based at SciLifeLab in Stockholm (Campus Solna) one of Europes leading centers for data-driven life science and biomedical research. SciLifeLab provides a uniquely collaborative environment at the interface of biology technology and AI with access to world-class microscopy infrastructure including advanced imaging platforms. This position is particularly well suited for ambitious students seeking to work at the frontier of microscopy and immunology in a highly dynamic and multidisciplinary research setting.

Qualification requirements

In order to be admitted to postgraduate education the applicant must have the general and specific entry qualification requirements must be met by the time the applicant is admitted to the PhD program at the Department of Biochemistry and Biophysics.

You meet general entry requirements if you have completed a second-cycle degree or completed courses equivalent to at least 240 higher education credits of which 60 credits must be in the second cycle or have otherwise acquired equivalent knowledge in Sweden or elsewhere.

In order to meet the specific entry requirementsfor acceptance in the Biophysics program the applicant must have passed courses within the first and second cycles of at least 120 credits in Physics or Chemistry and at the second level courses of at least 60 credits Biophysics Biochemistry or Physical Chemistry including a 30 credit Degree Project (thesis).

Selection

The selection amongst the eligible candidates will be based on their capacity to successfully complete the program. Important criteria when assessing this capacity are; documented knowledge and skill in the field of the thesis project written and oral proficiency in English the capacity for analytical thinking the ability to collaborate as well as creativity initiative and independence. The assessment will be based on previous experience and grades the quality of the degree project references relevant experience interviews and the candidates written motivation for seeking the position.

Admission Regulations for Doctoral Studies at Stockholm University.

About the employment

We offer a fixed-term employment as a doctoral student according to Chapter 5 of the Higher Education Ordinance (1993:100). The period of employment may not be longer than what corresponds to full-time doctoral education for four years. As a doctoral student you should primarily devote yourself to your own doctoral education but the employment may include work with education research and administration to a limited extent (maximum 20 %).

A new employment as a doctoral student is for a maximum of one year the employment is then renewed for a maximum of two years at a time.

Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Contact

For more information please contact Assistant Professor Juliette Griffié .

General information about the PhD programs can be given by the Professor and Director of Doctoral Studies Andreas Barth .

Application

Apply for the PhD student position at Stockholm Universitys recruitment system. Attach a personal letter and CV as well as the attachments requested in the application form. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement and that it is submitted before the deadline.

The instructions for applicants are available at: How to apply for a position.

Stockholm University contributes to the development of sustainable democratic society through knowledge enlightenment and the pursuit of truth.

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Employment Type : Full-Time
Experience: years
Vacancy: 1